US Open 2022: Serena Williams falls in third round, capping off illustrious career. It’s the end of an era. Serena Williams lost her third-round match at the U.S. Open on Friday in three sets to Alja Tomljanovic, capping off her illustrious career. Williams took a commanding 5-3 lead in the first set, well on her way to make the third round look easy. However, she lost four games in a row and lost the first set 7-5. But she came back with a vengeance in the second set. In fact, she utterly dominated early on. She answered by winning the first four games of the set, but Tomljanovic didn’t go down quietly. She won the next two games, and even came close to breaking Williams’ serve again, but the 23-time grand slam champion refused to let that happen. At deuce, she earned back-to-back points to clinch the game. Williams and her sister, Venus, lost in the first round of the women’s doubles tournament on Thursday. Williams retires with 23 grand slams – seven Wimbledons, seven Australian Opens, six U.S. Opens, and three French Opens – the second-most of all time.